Pancreatic cancer can be suffocated using Anti-diabetes drug
As per new study a drug which is commonly used to treat diabetes can suffocate the Pancreatic cancer cells which are effectively addicted to oxygen based metabolism. Cancer cells normally depend on glycolysis a type of metabolism which is does not use oxygen to generate their energy.
Pancreatic cancer can be suffocated using Anti-diabetes drugAs per researchers new study, not all cancer uses metabolism but the Pancreatic cancer stem cells can use more efficient form of metabolism called as oxidative phosphorylation or OXPHOS which uses oxygen.
As per analysis OXPHOS can uses a part of the cell called mitochondria which can be targeted with anti-diabetic drug metformin. However some PancSCs have ability to escape form this treatment but the investigators also found a way to prevent this and it can also force all the PancSCs to keep using OXPHOS.
Pancreatic cancer is one of the difficult type to treat because the symptoms and trigger diagnosis can be identified only at a late and advanced stage. People who are affected with this will not live longer than a year. Pancreatic cancer is also becoming one of the more common one due to obesity which has leading risk factors including metabolic syndrome and diabetes.